Organ on a chip technology to reduce side effects of radiotherapy

Professor Thierry, from the Future Industries Institute (FII) and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CBNS), is leading an international study using organ-on-a-chip technology to develop 3D models to test the effects of different levels and types of radiation.  The debilitating side effects of radiotherapy could soon be a thing of the past thanks to a new and exciting breakthrough by researchers

A microfluidic cell culture chip closely mimics the structure and function of small blood vessels within a disposable device the size of a glass slide, allowing researchers and clinicians to investigate the impact of radiotherapy on the body’s tissues.  To date, scientists have relied on testing radiotherapy on cells in a two-dimensional environment on a slide.

Professor Thierry, says the organ-on-a-chip technology could reduce the need for animal studies and irrelevant invitro work, both of which have major limitations.

An important finding of the study is that endothelial cells grown in the standard 2D culture are significantly more radiosensitive than cells in the 3D vascular network. This is significant because of the need to balance the effect of radiation on tumour tissues while preserving healthy ones.

The human microvasculature (blood vessel systems within organs) is particularly sensitive to radiotherapy and the model used in this study could potentially lead to more effective therapies with fewer side effects for cancer patients.

More than half of all cancer patients receive radiotherapy at least once in the course of their treatment. While it cures many cancers, the side effects can be brutal and sometimes lead to acute organ failure and long-term cardiovascular disease.

Prof Thierry’s team, including FII colleague Dr Chih-Tsung Yang and PhD student Zhaobin Guo, are working in close collaboration with the Royal Adelaide Hospital and Harvard University with support from the Australian National Fabrication Facility.

The researchers’ next step is to develop body-on-chip models that mimic the key organs relevant to a specific cancer type.